The efficacy of Zoledronic acid on the treatment of Postmenopausal osteoporosis

The efficacy of Zoledronic acid on the treatment of Postmenopausal osteoporosis

Osteoporosis is a systemic skeletal disease characterised by low bone mass and

deterioration of bone tissue, with a consequent increase in bone fragility and

susceptibility to fracture. Studies have shown that women after menopause are

at higher risk of developing osteoporosis but this condition may also affect men,

younger women and children. One in two women and one in five men over the

age of 50 will develop a bone fracture. Osteoporosis costs the NHS over 1.5

billion annually and has a large burden on the NHS in terms of costs and


The diagnosis of postmenopausal osteoporosis can be confirmed through the

history of the patient, bone mineral density and to a lesser extent parathyroid-

related causes. Broken wrists, hips and spinal bones are the most common

fractures in osteoporosis.



All papers relating to the efficacy of Zoledronic acid on the treatment of

postmenopausal osteoporosis were attached to my dairy. The search engines

that were adopted in this search use reliable journal sources such as “Nature”

and “Science”.

The first search engine that was used for this purpose is the MMU electronic

database. I replicated the same search strategy with MEDLINE database. I chose

MEDLINE because it is more clinically orientated and has more biomedically-

related data. After comparing the results, the relevant identical articles from the

two searches were combined whereas new ones were added to the list of

relevant articles. Moreover, all articles from both sources are from March 2007

until 2010.

Eligibility Criteria

All of the academic papers that were found are not exactly inclusive to my

question’s answer. For example, some of them have mentioned about

bisphosphonates other than Zoledronate such as oral and intravenous agents or

other therapies utilised in osteoporosis in males and females. Although, the

articles did not focus uniquely on my topic but they have been eligible for

incorporation. For instance, they have demonstrated vitamin D and four types of

bisphosphonate; alendronate, risedronate, ibandronate and zoledronate that

involve different methods of treatment of osteoporosis. Also, the papers have

indicated current and common clinical trials for treatment.


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